The MacB ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram-negative bacteria.Here, we review recent structural and functional data on MacB and its homologs.MacB has a fold that is distinct from other structurally characterized AB
Notwithstanding the well-recognized involvement of chronic neutrophilic inflammation in the initiation phase of many types of epithelial cancers, a growing body of evidence has also implicated these cells in the pathogenesis of the later phases of cancer development, specifically progression and spread.In Shaving Creams this setting, established tu
Abstract Background Rice (Oryza sativa L.) is a food crop for humans worldwide.However, temperature has an effect during the vegetative and reproductive stages.In high-latitude regions where rice is cultivated, cold stress is a major cause of yield loss and plant death.Research has identified a group of plant-specific transcription factors, DNA bin
Background Diamond-Blackfan anemia is a rare, pure red blood cell aplasia of childhood due to an intrinsic defect in erythropoietic progenitors.About 40% of patients display various malformations.Anemia is corrected by steroid treatment in more than 50% of cases; non-responders need chronic transfusions or stem cell transplantation.Defects in the R